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Exodus 2 Human/ 重組人次級非淋巴組織趨化因子CCL21

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Exodus 2 Human/ 重組人次級非淋巴組織趨化因子CCL21 產(chǎn)品編號：CHM-332
產(chǎn)品規(guī)格：5μg/20μg/1mg

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Exodus 2 Human/ 重組人次級非淋巴組織趨化因子CCL21

產(chǎn)品編號：CHM-332
產(chǎn)品規(guī)格：5μg/20μg/1mg

Synonyms	Small inducible cytokine A21, CCL21, Beta chemokine exodus-2, 6Ckine, Secondary lymphoid-tissue chemokine, SLC, chemokine （C-C motif） ligand 21, ECL, CKb9, TCA4, SCYA21, MGC34555.
Introduction	Chemokine （C-C motif） ligand 21 （CCL21） is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine （because it has six conserved cysteine residues instead of the four cysteines typical to chemokines）, exodus-2, and secondary lymphoid-tissue chemokine （SLC）. CCL21 is expressed predominantly in the lymph nodes and, in contrast to other CC chemokines, is chemotactic for lymphocytes. The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.
Description	Exodus-2 Human Recombinant produced in E.Coli as a single, non-glycosylated, polypeptide chain containing 111 amino acids and having a molecular mass of 12219 Dalton. The CCL21 is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered White lyophilized （freeze-dried） powder.
Formulation	The CCL21 was lyophilized from a concentrated （1mg/ml） solution in water containing no additives.
Solubility	It is recommended to reconstitute the lyophilized Exodus2 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Stability	Lyophilized Exodus-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL21 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
Purity	Greater than 95.0% as determined by SDS-PAGE.
Amino acid sequence	The sequence of the first five N-terminal amino acids was determined and was found to be, Ser-Asp-Gly-Gly-Ala.
Biological Activity	ED50 range = 100-400 ng/mL, determined by the chemotactic response of 5-10 day PHA and IL-2 stimulated PBMCs. Optimal concentration for individual application should be determined by a dose response assay.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.